Ревматоидният артрит (RA) е хронично възпалително заболяване, характеризиращо се с разрушаване на костите и хрущялите. Въпреки че етиологията му е неизвестна, се предполага, че хидроксилният радикал участва в патогенезата на RA. Наскоро беше доказано, че молекулярният водород (Н2) е селективен чистач на хидроксилния радикал. Също така е разработен методът за приготвяне на вода, съдържаща изключително висока концентрация на H2. Ние предположихме, че H2 във водата може да допълни конвенционалната терапия чрез намаляване на оксидативния стрес при RA. Двадесет пациенти с ревматоиден артрит (RA) пият 530 ml вода, съдържаща 4 до 5 ppm молекулен водород (вода с високо съдържание на H2) всеки ден в продължение на 4 седмици. След 4-седмичен период на измиване, пациентите пиеха водата с високо съдържание на H2 за още 4 седмици. 8-хидроксидезоксигуанин в урината (8-OHdG) и активност на заболяването (DAS28, с използване на нива на С-реактивен протеин [CRP]) се изчислява в края на всеки 4-седмичен период. Пиенето на вода с високо съдържание на H2 изглежда повишава концентрацията на H2 повече от наситената с H2 (1,6 ppm) вода in vivo. 8-OHdG в урината е значително намален средно с 14,3% (p <0,01). DAS28 също намалява от 3.83 на 3.02 (p <0.01) през същия период. След периода на измиване, както 8-OHdG в урината, така и средният DAS28 намаляват в сравнение с края на периода на пиене. По време на втория период на пиене, средният DAS28 е намален от 2,83 на 2,26 (p <0,01). 8-OHdG в урината не е намален допълнително, но остава под изходната стойност. Всички 5 пациенти с ранен RA (продължителност <12 месеца), които не показват антитела срещу циклични цитрулинирани пептиди (ACPA), са постигнали ремисия, и 4 от тях станаха без симптоми в края на проучването.
Резултатите показват, че хидроксилният радикал H2 ефективно намалява оксидативния стрес при пациенти с това състояние. Симптомите на RA се подобряват значително с високо съдържание на вода H2.
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