Addition of molecular hydrogen to hemodialysis solutions improves inflammatory responsesScientific Research


Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S.

DOI: 10.1093

Published on: 12/04/2010

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial 

Nephrology Dialysis Transplantation, Volume 25, Issue 9, September 2010, Pages 3026–3033,



Chronic inflammation in hemodialysis (HD) patients indicates a poor prognosis. However, treatment options are limited. Hydrogen (H2) improves oxidative and inflammatory damage to organs in animal models. We developed an HD system using a highly concentrated dissolved H2 dialysis solution and investigated the clinical implications.


A dialysis solution containing H2 (average 48 ppb) was prepared by mixing the dialysate concentrate with reverse osmosis water containing dissolved H2 produced by water electrolysis techniques. Subjects included 21 stable standard HD patients who switched to trial HD 3 times a week for 6 months.


No adverse clinical signs or symptoms were observed during the study. During the study period, a significant decrease in systolic blood pressure (SBP) before and after dialysis was observed, with a large number of patients achieving SBP < 140 mmHg after HD (baseline: 21%; 6 months: 62%; P < 0, 05). Changes in dialysis parameters were small, while plasma monocyte chemoattractant protein 1 (P<0.01) and myeloperoxidase (P<0.05) were significantly reduced.


Adding H2 to the hemodialysis solution improves inflammation and improves blood pressure control. The system could provide new treatment options for the control of uremia.




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