Hydrogen slows down agingScientific Research

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The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

DraganaZaniniaNikolaTodorovicaDarinkaKorovljevaValdemarStajeraJelenaOstojicbJelenaPuraccDanijelaKojiccElviraVukasinoviccSrdjanaDjordjievskicMironSopicdAzraGuzonjicdAnaNinicdSanjaErcegdSergej M.Ostojica



In this randomized controlled pilot study, we evaluated the effect of 6-month hydrogen-rich water (HRW) intake on multiple molecular and phenotypic biomarkers of aging in people aged 70 years and older. During the 6-month intervention period, 40 older adults (20 women) were randomly assigned to a parallel group design to receive 0.5 liters of HRW (15 ppm hydrogen) or a control beverage (0 ppm hydrogen) per day. Biomarkers assessed at baseline and 6-month follow-up were blood molecular markers (DNA and chromosomes, nutrient recognition, protein and lipid metabolism, oxidative stress and mitochondria, cellular aging, inflammation), brain metabolism, cognitive function , body function and body composition, resting blood pressure, facial skin characteristics, sleep outcomes and health-related quality of life. The mean age, weight, and height of study participants were 76.0 ± 5.6 years, 78.2 ± 16.1 kg, and 167.5 ± 11.5 cm, respectively. There was a significant interaction between treatment and time (p=0.049) for telomere length, which increased after HRW intervention (from 0.99±0.15 at baseline to 1.02±0.26 at follow-up) and decreased after drinking control water (from 0.92±0.26). 0.27 to 0.79 ± 0.15). Expression of a DNA methylation marker (tet-methylcytosine dioxygenase 2, TET2) increased at all 6-month follow-up, but HRW increased significantly more (0.81 ± 0.81 ± 0, 52 to 1.62 ± 0.66 in subsequent). ) compared to control water (from 1.13 ± 0.82 to 1.76 ± 0.87) (P = 0.040). A strong trend was found for the interaction between treatment and time in DNA methylation levels (p = 0.166), with methylation increasing (from 120.6 ± 39.8 ng at baseline to 126.6 ± 33,8 ng at follow-up) and decreasing in the HRW group After ingestion of control water (from 133.6 ± 52.9 ng to 121.2 ± 38.4 ng). HRW was superior to control water in increasing brain choline and NAA levels in left frontal gray matter, brain creatine in right parietal white matter, and brain NAA in right medial parietal gray matter (P<0, 05). No significant inter-intervention differences (P > 0.05) were found for the other endpoints, except that fecal standing performance was significantly improved after HRW intervention compared to control water (P = 0.01). Due to the pleiotropic mechanism of hydrogen action, this simple biomedical gas can be considered as a potential antiaging agent against several hallmarks of aging, including loss of function and shortening of telomere length. This study is registered with ClinicalTrials.gov (NCT04430803).