Hydrogen improves the immune system of lung cancer patientsScientific Research

Водородът потиска прогресията на Рак на Белия Дроб

original title: Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study.

1 Fuda Cancer Hospital of Jinan University; Fuda Cancer Institute, Guangzhou, Guangdong Province, China
2 Fuda Cancer Hospital of Jinan University, Guangzhou, Guangdong Province, China
3 Central Laboratory, Peking University Cancer Hospital, Beijing, China

DOI: 10.4103/2045-9912.304221

Published on: 25/12/2020


After standard therapy, traditional models of enhancing antitumor immunity include immune reconstitution (eg, adoptive immune cell therapy or immune-enhancing drugs) to prevent relapse. For patients with advanced NSCLC, we report here two targets, immunosenescence in advanced NSCLC and hydrogen inhalation for immune reconstitution. From July 1 to September 25, 2019, 20 patients with non-small cell lung cancer were enrolled to measure immunosenescence in peripheral blood lymphocyte subsets, including T cells, natural killer/natural killer T cells, and gamma delta-T Cells. A two-week hydrogen inhalation was performed while awaiting treatment-related tests. All patients inhaled a mixture of hydrogen (66.7%) and oxygen (33.3%) daily for 4 hours at a gas flow rate of 3 L/min.None of the patients received any standard treatment during hydrogen inhalation. After the preconditioning experiment, the main indicators of immunosenescence were observed. Abnormally high indices included depleted cytotoxic T cells, senescent cytotoxic T cells, and killer Vδ1 cells. After 2 weeks of hydrogen therapy, the number of exhausted and senescent cytotoxic T cells decreased to the normal range and the number of killer Vδ1 cells increased. Abnormally low indicators included functional helper and cytotoxic T cells, Th1, all natural killer T cells, natural killer and Vδ2 cells. After 2 weeks of hydrogen therapy, all six cell subsets increased within normal ranges. Current data suggest that immunosenescence in advanced non-small cell lung cancer affects nearly all lymphocyte subsets, and that 2 weeks of hydrogen treatment can significantly improve most of these metrics.The study was approved by the Ethics Committee of Fuda Cancer Hospital, Jinan University, China on December 7, 2018 (approval number Fuda20181207), and was registered with ClinicalTrials.gov on January 24, 2019 (ID: NCT03818347).

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