Hydrogen resuscitation, a new cytoprotective approachScientific Research


Xing-Feng Zheng, Xue-Jun Sun, Zhao-Fan Xia

DOI: 10.1111

Published on: 19/01/2021

Hydrogen resuscitation, a new cytoprotective approach

Xing-Feng Zheng,Xue-Jun Sun,Zhao-Fan Xia



1. Hydrogen is a colorless, odorless and tasteless flammable gas. Hydrogen is considered a physiologically inert gas and is widely used in deep-sea diving medicine. In mammals, the fermentation of indigestible carbohydrates by gut bacteria produces endogenous hydrogen gas and absorbs it into the systemic circulation.

2. Recent evidence suggests that hydrogen is a potent antioxidant, anti-apoptotic and anti-inflammatory agent, and thus may have potential medicinal value. This review evaluates the concept of “hydrogen resuscitation” based on the knowledge that hydrogen therapy is effective in protecting cells, tissues and organs from oxidative damage and helping them recover from dysfunction.

3. Hydrogen therapy can be administered by inhalation, administration of hydrogen-rich liquids, or methods that affect endogenous hydrogen production.

4. Studies have shown that hydrogen resuscitation is cytoprotective in various cell types and disease models, including ischemia-reperfusion injury, inflammation, toxicity, trauma, and metabolic diseases. The underlying mechanism may be the selective elimination of hydroxyl radicals, although other mechanisms may also be involved (eg, hydrogen as a gaseous signaling molecule).

5. Hydrogen resuscitation may have several potential advantages over current pharmacotherapies targeting oxidative damage. However, more work is needed to determine the exact mechanism of hydrogen action and validate its therapeutic potential in the clinical setting.


Zhao-Fan Xia, Department of Burn Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China. Email: xiazhaofan@163.com


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