Hydrogen-rich water as an ergogenic agentScientific Research


Sergej M. & Marko D. Stojanovic

DOI: 10.1080

Published on: 21/09/2023

Hydrogen-Rich Water Affected Blood Alkalinity in Physically Active Men


The potential application of an effective and safe alkalizing agent in the treatment of metabolic acidosis may be of particular interest in persons with elevated plasma acidity, such as those with exercise-induced acidosis in B. In this study, we tested the hypothesis that oral administration of 2 L of hydrogen-rich water (HRW) per day for 14 days increases arterial alkalinity at baseline and after exercise compared with placebo. The study was a randomized, double-blind, placebo-controlled study that recruited 52 potentially healthy, physically active male volunteers. Twenty-six participants received HRW for 14 days and 26 participants received placebo (tap water). Arterial pH, partial pressure of carbon dioxide (pCO2), and bicarbonate were measured at baseline and post-exercise baseline (day 0) and at the end of the intervention period (day 14). After 14 days of intervention, HRW intake significantly increased fasting arterial pH by 0.04 (95% confidence interval; 0.01-0.08; p<0.001) and post-exercise pH by 0.07 (95% confidence interval, 0.01-0.10, p=0.03) In the HRW study, fasting bicarbonate was significantly higher after the dosing regimen than before the dosing (30.5 ± 1.9 mEq/L vs. 28.3 ± 2.3 mEq/L; p<0.0001). No volunteers withdrew before the end of the study, and no participants reported any annoying side effects from the supplement. These results support the hypothesis that HRW administration is safe and may have an alkalizing effect in young physically active men.


The authors declare that they have no competing interests. The authors thank study participants for their commitment. We thank Radmila Vrzic for assistance with the retrieval of biochemical data; Mirjana Stojanovic for statistical support; and the staff of the Exercise Physiology Laboratory Bojan Medjedovic, Dragoljub Veljovic, and Kristina Kanostrevac.


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