Hydrogen therapy in sepsisScientific Research


Yijun Zheng и Duming Zhu

DOI: 10.1155

Published on: 20/06/2016

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Academic Editor: Xiao-Kang Li


Molecular hydrogen therapy has been extensively studied and studied since it was proposed in 2007. Many animal experiments have been performed in various disease areas, such as B. cerebral infarction, ischemia-reperfusion injury, Parkinson’s disease, type 2 diabetes, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, Stress ulcers, acute sports injuries, mitochondrial and inflammatory diseases and acute erythematous dermatoses and other pathological processes or diseases. Molecular hydrogen therapy is noted because it also has protective effects in patients with sepsis. The efficacy of molecular hydrogen therapy on sepsis is manifested in basic vital signs, organ function (brain, lung, liver, kidney, small intestine, etc.), survival rate, etc. Molecular hydrogen therapy can significantly reduce the release of inflammatory factors and oxidative stress damage. Thereby reducing the damage of sepsis to various organ functions and improving the survival rate. Molecular hydrogen therapy is a prospective approach to sepsis.


Molecular hydrogen therapy has a protective effect on sepsis, which is confirmed by pathological biopsy, inflammatory/anti-inflammatory factor levels, oxidative stress response, behavioral experiments and other organ function-related indicators. Although the effect of molecular hydrogen therapy on the liver and kidneys is controversial, the mainstream view is that molecular hydrogen therapy is beneficial to the brain, lung, liver, kidney, small intestine and other organs.

Molecular hydrogen therapy combined with oxygen therapy or fluid resuscitation can reduce oxygen free radical damage, fluid and vasoactive drug use, and fluid overload. Therefore, molecular hydrogen therapy can reduce the complications of oxygen therapy and fluid resuscitation.

However, most of the research results come from animal experiments, and there are few reports of clinical studies. More clinical evidence is needed.

In conclusion, molecular hydrogen therapy is a promising approach to attenuate organ damage, improve prognosis, and reduce mortality in sepsis.


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