Hydrogen water in metabolic syndromeScientific Research
Effects of taking hydrogen water in metabolic syndrome
Metabolic syndrome is associated with several medical risk factors—including dyslipidemia, hyperglycemia, and obesity—which has become a global pandemic. The consequences of this condition increase the risk of cardiovascular and neurological diseases and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and disturbances in cellular homeostasis. Molecular hydrogen (H2) can attenuate oxidative stress, improve cellular function and reduce chronic inflammation.
Preclinical and clinical studies have shown promising effects of hydrogen-enriched water (HRW) on specific features of the metabolic syndrome, but the effects of long-term ingestion of high-concentration HRW hydrogen water in this prevalent condition remain poorly addressed.
Methods: We conducted a randomized, double-blind, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to obtain baseline clinical data, followed by randomization to either placebo or highly concentrated hydrogen water HRW (> 5.5 mmol H 2 per day) for 24 weeks.
Ingestion of HRW hydrogenated water significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis compared with placebo ( P <0.05). Additionally, hydrogen intake showed a tendency to promote a slight reduction in body mass index and waist-to-hip ratio.
Our results provide further confidence that high-concentration HRW hydrogen water may have promising effects as a therapeutic modality for mitigating metabolic syndrome risk factors.