Transperitoneal administration of hydrogen suppresses peritoneal and systemic oxidative stressScientific Research
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity
Medical Gas Research volume 3
Oxidative stress (OS) associated with glucose breakdown products such as methylglyoxal has been reported to be associated with worsening peritoneal function in patients treated with peritoneal dialysis (PD). However, the use of antioxidants in general is limited due to their deleterious effects. This study aimed to elucidate the effects of a novel antioxidant molecular hydrogen (H2) on peritoneal OS using albumin redox status as a marker.
Effluent and blood samples from 6 normal PD patients were obtained during peritoneal equilibration testing using standard dialysate and hydrogen-rich dialysate. Determination of the redox state of albumin in wastewater and blood using high performance liquid chromatography.
The H2-enriched dialysate (62.31 ± 11.10%) had significantly higher mean fractions of reduced albumin (ƒ(HMA)) in the effluent than the standard dialysate (54.70 ± 13.08%). Likewise, serum ƒ(HMA) was significantly higher in hydrogen-rich dialysate (65.75 ± 7.52%) than in standard dialysate (62.44 ± 7.66%).
Intraperitoneal administration of H2 reduces peritoneal and systemic OS.
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