{"id":15173,"date":"2023-07-17T15:59:32","date_gmt":"2023-07-17T12:59:32","guid":{"rendered":"https:\/\/hho-bulgaria.com\/hydrogen-therapy-in-the-treatment-of-colon-cancer-colorectal-carcinoma\/"},"modified":"2026-04-02T04:54:23","modified_gmt":"2026-04-02T01:54:23","slug":"hydrogen-therapy-in-the-treatment-of-colon-cancer-colorectal-carcinoma","status":"publish","type":"page","link":"https:\/\/hho-bulgaria.com\/en\/hydrogen-therapy-in-the-treatment-of-colon-cancer-colorectal-carcinoma\/","title":{"rendered":"Hydrogen Therapy in the Treatment of Colon Cancer (Colorectal Carcinoma)"},"content":{"rendered":"
[vc_row content_placement=”middle” css=”.vc_custom_1681918844276{margin: 0px !important;padding: 0px !important;background: #f5f5f1 url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2023\/04\/Vodorodana-Terapia-Rak-na-Debeloto-Chervo_BG-1.jpg?id=13790) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”mobile-bg-none”][vc_column width=”1\/2″ css=”.vc_custom_1677691567909{padding-right: 5% !important;padding-bottom: 5% !important;padding-left: 5% !important;}” el_class=”bg-grdnt”][vc_column_text css=”.vc_custom_1681918814399{padding-top: 2rem !important;padding-right: 10% !important;padding-left: 10% !important;}”]\n
\n

Hydrogen Therapy in
\nColon Cancer Treatment
\n(Colorectal Carcinoma)<\/strong><\/span><\/p>\n

Prepared by:
\nDoctor Ivan Vlasov<\/strong><\/p>\n

The Application of Hydrogen in the Complex Treatment of Colon Cancer<\/h1>\n

Thanks to its distinctive antitumor properties, Hydrogen Therapy reduces oxidative stress and suppresses tumor progression<\/strong> in the treatment of Colon Cancer (Colorectal Carcinoma).<\/p>\n

According to a study published in the medical “World Journal of Gastrointestinal Oncology” (World Journal of Gastrointestinal Oncology) –<\/a> applied in combination with chemotherapy, hydrogen significantly increases the positive results while reducing the unwanted side effects of chemotherapy.<\/strong><\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1676647424333{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}” offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm”][vc_single_image image=”13787″ img_size=”full” alignment=”right” css=”.vc_custom_1681915052959{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][\/vc_column][\/vc_row][vc_section css=”.vc_custom_1676641817421{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_row css=”.vc_custom_1677692561989{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #008860 !important;}”][vc_column css=”.vc_custom_1631774665589{padding-top: 7.5% !important;padding-right: 10% !important;padding-bottom: 7.5% !important;padding-left: 10% !important;}”][vc_column_text css=”.vc_custom_1680514285842{padding-bottom: 3rem !important;}”]\n

\n

Results of the treatment of Colorectal Carcinoma
\nwith Hydrogen (H2) and 5-Fluorouracil (5-FU)<\/h3>\n

(Clinical Study published in the scientific “World Journal of Gastrointestinal Oncology”)<\/p>\n<\/div>\n[\/vc_column_text]

0<\/div>%<\/span><\/span>
<\/span>tumor size reduction in Chemotherapy (5-Fluorouracil)<\/div><\/div><\/div>
0<\/div>%<\/span><\/span>
<\/span>tumor size reduction in Hydrogen Therapy<\/div><\/div><\/div>
0<\/div>%<\/span><\/span>
<\/span>tumor size reduction in combined treatment (Hydrogen Therapy + Chemotherapy)<\/div><\/div><\/div><\/div>[vc_row_inner css=”.vc_custom_1677692543264{padding-top: 3rem !important;}”][vc_column_inner width=”1\/2″][vc_column_text]\n
\n

Colon cancer can be completely curable<\/strong> with early diagnosis and aggressive surgical treatment of the tumor and metastases, followed by modern chemotherapy.<\/p>\n

5-Fluorouracil (5-FU)<\/a> is the most commonly used modern chemotherapy for Colorectal Carcinoma, which is distinguished by many benefits for the patient, but also with significant side effects.<\/p>\n

According to the mentioned clinical study, hydrogen leads to a significant improvement in the results of treatment with 5-Fluorouracil, while at the same time reducing the unwanted effects caused by chemotherapy.<\/strong><\/p>\n<\/div>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_column_text]\n

\n

Hydrogen Therapy is well tolerated and has a high potential to reduce the side effects of carcinoma treatment and improve long-term prognosis.<\/p>\n

Applied alone, hydrogen inhalations reduce oxidative stress, and in combination with 5-FU, in a synergistic manner, significantly suppress tumor progression.<\/strong><\/p>\n

To the Original Study<\/a><\/p>\n<\/div>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row equal_height=”yes” content_placement=”middle” el_class=”mobile-bg-none bg-fxd bgp-left” css=”.vc_custom_1775002429614{margin-bottom: 0px !important;padding-bottom: 0px !important;background-image: url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2023\/04\/Vodorodana-Terapia-Rak-na-Debeloto-Chervo_BG-2.jpg?id=13782) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/2″ css=”.vc_custom_1775002393994{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1775002441609{margin-bottom: 0px !important;padding-top: 0px !important;padding-bottom: 0px !important;}”][vc_row_inner css=”.vc_custom_1681918856373{margin: 0px !important;padding: 0px !important;}”][vc_column_inner offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm” css=”.vc_custom_1775002452481{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_single_image image=”13779″ img_size=”full” alignment=”center” css=”.vc_custom_1681918883749{margin: 0px !important;padding: 0px !important;}”][\/vc_column_inner][\/vc_row_inner][vc_column_text css=”.vc_custom_1775002761440{margin-bottom: 0px !important;padding-top: 10% !important;padding-right: 10% !important;padding-bottom: 10% !important;padding-left: 10% !important;}”]\n

\n

Colorectal Carcinoma (Colon Cancer)<\/h2>\n

The incidence of Colorectal Carcinoma (CRC) is increasing in all industrialized countries.<\/p>\n

Colorectal cancer is the second leading cause of death<\/strong> after lung cancer in men and breast cancer in women. Its frequency in our country is 50\/100,000 newly discovered cases per year.<\/p>\n

The incidence of CRC is highest in people between the ages of 60 and 80, but it can also occur in younger people. Colorectal Carcinoma occurs almost equally in both sexes, while Rectal Carcinoma is more common in men.<\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1775002604339{margin-top: 0px !important;padding-top: 0px !important;}”][vc_column css=”.vc_custom_1775002615405{margin-top: 0px !important;padding-top: 0px !important;}”][vc_raw_html]JTVCcHJvZHVjdHMtY3RhJTIwbGFuZyUzRCUyMmVuJTIyJTIwcHJvZHVjdDFfdXJsJTNEJTIyaHR0cHMlM0ElMkYlMkZoaG8tYnVsZ2FyaWEuY29tJTJGZW4lMkZwcm9kdWN0JTJGaGJzMTAtaHlkcm9nZW4td2F0ZXItYnJlYXRoaW5nLW1hY2hpbmUlMkYlMjIlMjBwcm9kdWN0Ml91cmwlM0QlMjJodHRwcyUzQSUyRiUyRmhoby1idWxnYXJpYS5jb20lMkZlbiUyRnByb2R1Y3QlMkZoMmJvb3N0ci1taW5pLWh5ZHJvZ2VuLXdhdGVyLXN5c3RlbSUyRiUyMiU1RA==[\/vc_raw_html][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1677690448413{margin-bottom: 0px !important;padding-top: 5% !important;padding-right: 5% !important;padding-bottom: 0px !important;padding-left: 5% !important;}”][vc_column][vc_column_text]\n

The place of Hydrogen Therapy<\/span>
\nin complex treatment
\nof Colorectal Carcinoma<\/h2>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1775083219718{margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 3rem !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-image: url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2026\/04\/Hydrogen-Therapy-Colon-Cancer-Colorectal-Carcinoma_Tumor-1.jpg?id=37286) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”mobile-bg-none bg-fxd bgp-rght”][vc_column width=”1\/2″ css=”.vc_custom_1655900159913{margin: 0px !important;padding: 0px !important;}”][vc_column_text css=”.vc_custom_1682470596897{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 3rem !important;padding-bottom: 3rem !important;padding-left: 3rem !important;}”]\n
\n

Hydrogen Suppresses Tumor Growth and Enhances Antitumor Efficacy of 5-Fluorouracil in a Tumor Xenograft Model of Colon Cancer (Colorectal Carcinoma)<\/span><\/h3>\n

In the study cited above, the influence of hydrogen on tumor growth was investigated in a xenograft model of Colorectal Carcinoma (CRC).<\/p>\n

The results obtained prove that the application of hydrogen therapy significantly supports the treatment with 5-Fluorouraci<\/span>l and further reduces tumor progression<\/strong> (Figure 1).<\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1675680555851{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}” offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm”][vc_single_image image=”37291″ img_size=”full” alignment=”center” css=”.vc_custom_1775083304912{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #e0dddf !important;}”][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1775083370139{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-image: url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2026\/04\/Hydrogen-Therapy-Colon-Cancer-Colorectal-Carcinoma_Tumor-2.jpg?id=37296) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”mobile-bg-none bg-fxd bgp-rght”][vc_column width=”1\/2″ css=”.vc_custom_1655900159913{margin: 0px !important;padding: 0px !important;}”][vc_column_text css=”.vc_custom_1682471209458{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 3rem !important;padding-bottom: 3rem !important;padding-left: 3rem !important;}”]\n

\n

Specifically, the mean control tumor size was 2698.85 mm3<\/sup>, while the mean 5-FU chemotherapy tumor size was 2097.32 mm3<\/sup> (22.3% tumor growth suppression).<\/p>\n

The main disadvantage of 5-Fluorouracil<\/span> (chemotherapy) treatment is that it causes many unwanted side effects.<\/p>\n

According to a number of medical studies, hydrogen helps to reduce these effects, having a beneficial effect on liver function.<\/p>\n

In comparison, the suppressive effect of hydrogen on tumor growth was slightly more potent than that of 5-FU<\/span> (2047.23 mm3<\/sup><\/span> vs. 2097.32<\/span> mm3),<\/sup> but not as effective as the combination therapy (H2 + 5-FU) .<\/span><\/p>\n

The results achieved with hydrogen therapy were 24.1% suppression of tumor progression compared to control tumor size (2047.23 mm3<\/sup><\/span> vs. 2698.85 mm3)<\/sup>.<\/span><\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1675680555851{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}” offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm”][vc_single_image image=”37301″ img_size=”full” alignment=”center” css=”.vc_custom_1775083431988{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #e0dddf !important;}”][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1775083468807{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-image: url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2026\/04\/Hydrogen-Therapy-Colon-Cancer-Colorectal-Carcinoma_Tumor-3.jpg?id=37306) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”mobile-bg-none bg-fxd bgp-rght”][vc_column width=”1\/2″ css=”.vc_custom_1682473402780{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 5% !important;padding-bottom: 0px !important;padding-left: 5% !important;}”][vc_column_text]\n

\n

Combination therapy, on the other hand, resulted in the greatest suppression of CRC tumor size \u2013 with a mean size of 1177.5 mm3<\/sup> achieved (56.4% suppression compared to control). An approximately 30% decrease in tumor weight was also observed (Figure 2).<\/p>\n

To date, more than 1,500 scientific studies have been published investigating the therapeutic effect of hydrogen in nearly 170 diseases, including the treatment of Colon Cancer (Colorectal Carcinoma).<\/p>\n

Simultaneous administration of Hydrogen Inhalations and 5-Fluorouracil<\/span> significantly reduced the weight and size of the CRC tumor,<\/strong> as well as the amount of collagen and fibrosis, slightly increasing oxidative stress and decreasing antioxidant activity.<\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1675680555851{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}” offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm”][vc_single_image image=”37311″ img_size=”full” alignment=”center” css=”.vc_custom_1775083522265{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #e0dddf !important;}”][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1775083560897{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-image: url(https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2026\/04\/Hydrogen-Therapy-Colon-Cancer-Colorectal-Carcinoma_Tumor-4.jpg?id=37316) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”mobile-bg-none bg-fxd bgp-rght”][vc_column width=”1\/2″ css=”.vc_custom_1682473420916{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 5% !important;padding-bottom: 0px !important;padding-left: 5% !important;}”][vc_column_text]\n

\n

In addition – Hydrogen Therapy is distinguished by a beneficial effect on the liver function<\/strong> of patients undergoing chemotherapy.<\/p>\n

In addition to the positive effect on chemotherapy, hydrogen inhalations have also been reported to have a protective effect against radiation-induced bone marrow damage, as well as a reduction in other side effects of radiotherapy.<\/strong><\/p>\n

From the above, it is clear that the indication for the application of combined therapy, including hydrogen inhalations, is Class C1 and Class C2 according to the modified Dukes classification, i.e. with invasion of the entire colon wall, adjacent structures, metastases in lymph nodes, distant metastases.<\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1675680555851{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}” offset=”vc_hidden-lg vc_hidden-md vc_hidden-sm”][vc_single_image image=”37321″ img_size=”full” alignment=”center” css=”.vc_custom_1775083606035{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #e0dddf !important;}”][\/vc_column][\/vc_row][vc_row][vc_column][vc_row_inner][vc_column_inner width=”1\/2″ css=”.vc_custom_1682476183508{padding-top: .5rem !important;padding-right: 10% !important;padding-bottom: .5rem !important;padding-left: 10% !important;}”][vc_single_image image=”37326″ img_size=”full” alignment=”center” css=”.vc_custom_1775083651114{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][\/vc_column_inner][vc_column_inner width=”1\/2″ css=”.vc_custom_1682476206699{padding-top: .5rem !important;padding-right: 10% !important;padding-bottom: .5rem !important;padding-left: 10% !important;}”][vc_single_image image=”37331″ img_size=”full” alignment=”center” css=”.vc_custom_1775083738720{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][\/vc_section][vc_section css=”.vc_custom_1676641817421{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_row equal_height=”yes” content_placement=”middle” el_class=”mobile-bg-none bg-fxd bgp-rght” css=”.vc_custom_1680528010028{padding-top: 2rem !important;padding-right: 5% !important;padding-bottom: 2rem !important;padding-left: 5% !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/2″ css=”.vc_custom_1655472140282{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_column_text css=”.vc_custom_1682470530802{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”]\n

\n

Conclusion<\/h3>\n

Safe and well-tolerated adjuvant therapy with the potential to reduce the side effects of conventional cancer therapy while improving outcomes is of great interest to colorectal cancer patients and their treating physicians and is seen in Hydrogen Therapy.<\/p>\n

It has an antitumor effect and also reduces and reduces the side effects of conventional treatment with 5-Fluorouracil.<\/p>\n

Combining both types of treatment has a suppressive effect on tumor progression.<\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1655465701557{padding-top: 1rem !important;padding-bottom: 0px !important;}”][vc_single_image image=”13775″ img_size=”full” alignment=”center” css=”.vc_custom_1681915735281{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 5% !important;padding-right: 5% !important;padding-bottom: 5% !important;padding-left: 5% !important;}”][\/vc_column][\/vc_row][\/vc_section][vc_row css=”.vc_custom_1775002036459{margin-top: 0px !important;padding-top: 0px !important;}”][vc_column css=”.vc_custom_1775002050766{margin-top: 0px !important;padding-top: 0px !important;}”][vc_column_text css=”.vc_custom_1775002875299{margin-top: 0px !important;margin-bottom: 3rem !important;padding-top: 0px !important;}”]

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