{"id":31832,"date":"2024-02-26T22:39:41","date_gmt":"2024-02-26T20:39:41","guid":{"rendered":""},"modified":"2024-05-23T20:23:07","modified_gmt":"2024-05-23T17:23:07","slug":"hydrogen-in-endometrial-uterine-cancer-treatment","status":"publish","type":"post","link":"https:\/\/hho-bulgaria.com\/en\/hydrogen-in-endometrial-uterine-cancer-treatment\/","title":{"rendered":"Hydrogen in Endometrial Uterine Cancer Treatment"},"content":{"rendered":"<h2 data-sourcepos=\"1:1-1:74\">Hydrogen shows promise in treating the most common gynecological cancer<\/h2>\n<h3 data-sourcepos=\"3:1-3:13\"><strong>Abstract:<\/strong><\/h3>\n<p data-sourcepos=\"5:1-5:346\">Hydrogen gas has been shown to have potential therapeutic effects against endometrial cancer, the most common gynecological cancer worldwide. A 2019 study conducted at Shanghai University hospitals and laboratories aimed to evaluate the antitumor activity of hydrogen and elucidate its underlying molecular mechanisms in endometrial cancer cells.<\/p>\n<h3 data-sourcepos=\"7:1-7:12\"><strong>Methods:<\/strong><\/h3>\n<p data-sourcepos=\"9:1-9:420\">The study employed two human endometrial cancer cell lines. Endometrial cancer cells were cultured in a hydrogen-enriched environment for 24 hours. Six replicates were used to assess the quality of the results, with cells divided into hydrogen-treated and control groups. RNA sequencing was performed to investigate the roles of signaling pathways and functional gene groups in hydrogen-treated endometrial cancer cells.<\/p>\n<h3 data-sourcepos=\"11:1-11:17\"><strong>Key Findings:<\/strong><\/h3>\n<p data-sourcepos=\"13:1-13:571\">Hydrogen was found to induce apoptosis, or programmed cell death, in endometrial cancer cells. Apoptosis levels in endometrial cancer cells were significantly increased following 24-hour hydrogen treatment compared to the control group. To assess the potential role of hydrogen therapy in combination with radiotherapy, hydrogen-treated cancer cells were exposed to radiation. The results demonstrated that the combination of hydrogen therapy and radiotherapy enhanced the rate of programmed cell death in tumors by approximately 60% compared to hydrogen-untreated cells.<\/p>\n<h3 data-sourcepos=\"15:1-15:15\"><strong>Discussion:<\/strong><\/h3>\n<p data-sourcepos=\"17:1-17:563\">Obesity and insulin resistance are considered risk factors for endometrial cancer. Molecular hydrogen has been demonstrated to have therapeutic potential for type 2 diabetes, metabolic syndrome, and various inflammatory diseases. Hydrogen can easily penetrate cell biological membranes and diffuse into the cytosol, mitochondria, and nucleus. It is administered as an inert gas for inhalation at normal body temperature or dissolved in water to produce hydrogen water or hydrogen saline, offering anti-inflammatory approaches for treating pathological conditions.<\/p>\n<h3 data-sourcepos=\"19:1-19:15\"><strong>Conclusion:<\/strong><\/h3>\n<p data-sourcepos=\"21:1-21:139\">The findings of this study support the notion that molecular hydrogen holds promise as a novel therapeutic approach for endometrial cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-\u03baB pathways<\/p>\n","protected":false},"author":1,"featured_media":17900,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[130],"tags":[],"disease":[846],"body-organ":[1042],"applications":[688],"test_subjects":[1520],"report-topic":[],"class_list":["post-31832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hydrogen-health","disease-cancer","body-organ-uterus-2","applications-culture-media-2","test_subjects-cell-culture-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hydrogen in Endometrial Uterine Cancer Treatment<\/title>\n<meta name=\"description\" content=\"RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-\u03baB pathways\" \/>\n<meta name=\"robots\" content=\"index, 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