{"id":16731,"date":"2023-08-21T14:46:55","date_gmt":"2023-08-21T11:46:55","guid":{"rendered":"https:\/\/hho-bulgaria.com\/?post_type=green-hydrogen-news&#038;p=16731"},"modified":"2023-08-21T14:46:55","modified_gmt":"2023-08-21T11:46:55","slug":"hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats","status":"publish","type":"green-hydrogen-news","link":"https:\/\/hho-bulgaria.com\/fr\/green-hydrogen-news\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\/","title":{"rendered":"Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats"},"content":{"rendered":"<div class=\"abstract-holder\">\n<h2 class=\"abstract-title\">Abstract:<\/h2>\n<p>Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN. This paper aimed to evaluate the effects of exogenous hydrogen to reduce the severity of DPN in streptozotocin-induced diabetic rats. Compared with hydrogen-rich saline treatment, hydrogen inhalation significantly reduced blood glucose levels in diabetic rats in the 4th and 8th weeks. With regard to nerve function, hydrogen administration significantly attenuated the decrease in the velocity of motor nerve conduction in diabetic animals. In addition, hydrogen significantly attenuated oxidative stress by reducing the level of malondialdehyde, reactive oxygen species, and 8-hydroxy-2-deoxyguanosine and meaningfully enhanced the antioxidant capability by partially restoring the activities of superoxide dismutase. Further studies showed that hydrogen significantly upregulated the expression of nuclear factor erythroid-2-related factor 2 and downstream proteins such as catalase and hemeoxygenase-1 in the nerves of diabetic animals. Our paper showed that hydrogen exerts significant protective effects in DPN by downregulating oxidative stress via the pathway of nuclear factor erythroid-2-related factor 2, which suggests its potential value in clinical applications.<\/p><\/div>\n<div class=\"attribute-table\">\n<div class=\"table-responsive\"><\/div>\n<table class=\"table table-bordered table-striped table-hover align-middle\">\n<tbody>\n<tr>\n<th>Publish Year<\/th>\n<td>2023<\/td>\n<\/tr>\n<tr>\n<th>Country<\/th>\n<td>China<\/td>\n<\/tr>\n<tr>\n<th>Rank<\/th>\n<td>Positive<\/td>\n<\/tr>\n<tr>\n<th>Journal<\/th>\n<td>Medical Gas Research<\/td>\n<\/tr>\n<tr>\n<th>Primary Topic<\/th>\n<td>Brain<\/td>\n<\/tr>\n<tr>\n<th>Secondary Topic<\/th>\n<td>Diabetes<\/td>\n<\/tr>\n<tr>\n<th>Model<\/th>\n<td>Rat<\/td>\n<\/tr>\n<tr>\n<th>Tertiary Topic<\/th>\n<td>Diabetic Peripheral Neuropathy<\/td>\n<\/tr>\n<tr>\n<th>Vehicle<\/th>\n<td>Gas<\/td>\n<\/tr>\n<tr>\n<th>pH<\/th>\n<td>N\/A<\/td>\n<\/tr>\n<tr>\n<th>Application<\/th>\n<td>Inhalation<\/td>\n<\/tr>\n<tr>\n<th>Comparison<\/th>\n<td><\/td>\n<\/tr>\n<tr>\n<th>Complement<\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN<\/p>\n","protected":false},"featured_media":16727,"parent":0,"menu_order":0,"template":"","news-category":[],"class_list":["post-16731","green-hydrogen-news","type-green-hydrogen-news","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats &#187; HHO \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f | HHO Bulgaria<\/title>\n<meta name=\"description\" content=\"Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hho-bulgaria.com\/fr\/green-hydrogen-news\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats &#187; HHO \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f | HHO Bulgaria\" \/>\n<meta property=\"og:description\" content=\"Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hho-bulgaria.com\/fr\/green-hydrogen-news\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\/\" \/>\n<meta property=\"og:site_name\" content=\"HHO \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f | HHO Bulgaria\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HHOBulgaria\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hho-bulgaria.com\/wp-content\/uploads\/2023\/08\/12035_2023_3342_Fig1_HTML.png\" \/>\n\t<meta property=\"og:image:width\" content=\"685\" \/>\n\t<meta property=\"og:image:height\" content=\"478\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hho-bulgaria.com\\\/fr\\\/green-hydrogen-news\\\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\\\/\",\"url\":\"https:\\\/\\\/hho-bulgaria.com\\\/fr\\\/green-hydrogen-news\\\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\\\/\",\"name\":\"Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats &#187; HHO \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f | HHO Bulgaria\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hho-bulgaria.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/hho-bulgaria.com\\\/fr\\\/green-hydrogen-news\\\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/hho-bulgaria.com\\\/fr\\\/green-hydrogen-news\\\/hydrogen-exerts-neuroprotective-effects-by-inhibiting-oxidative-stress-in-experimental-diabetic-peripheral-neuropathy-rats\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/hho-bulgaria.com\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/12035_2023_3342_Fig1_HTML.png\",\"datePublished\":\"2023-08-21T11:46:55+00:00\",\"description\":\"Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. 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