Hydrogen-rich water in patients with interstitial cystitis and painful bladder syndromeScientific Research


Seiji Matsumoto
Tomohiro Ueda
Hidehiro Kakizaki

DOI: 10.1016

Published on: 01/02/2023

Effect of Supplementation With Hydrogen-rich Water in Patients With Interstitial Cystitis/Painful Bladder Syndrome



To study the efficacy of hydrogen-rich water in the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS).


We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable IC/PBS symptoms for ≥12 weeks after hydrocystitis, an Interstitial Cystitis Symptom Index score ≥7, and bladder pain (Interstitial Cystitis Symptom Index Question 4) ≥4. They were randomized 2:1 to receive hydrogen-rich water or placebo water for 8 weeks. Symptoms were assessed using the Interstitial Cystitis Symptom Index, Interstitial Cystitis Problem Index, Patient Symptom Scale for Pelvic Pain and Parsons Urgency/Frequency, Bladder Pain Score on the Visual Analogue Scale, and a standard 3-day voiding diary. The primary outcome was improvement in patient-reported symptoms as assessed after treatment.


A total of 30 participants (29 women and 1 man, age 64.0 ± 14.8 years) participated in the study, and 2 patients (both women) withdrew from the study. Bladder pain scores were significantly lower in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from placebo, although supplementation with hydrogen-rich water was extremely effective in improving bladder pain scores in 11% of patients.


The results of this study do not support the use of hydrogen-rich water supplementation for the treatment of IC/PBS patients.


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