Hydrogen-rich water improves liver function in patients with chronic hepatitis BScientific Research


Chunxiang Xia M.D., Wenwu Liu Ph.D., Dongxiao Zeng B.A., Liyao Zhu B.A., Xiaoli Sun B.A., Xuejun Sun Ph.D.

DOI: 10.1111

Published on: 13/06/2013

Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B



To investigate the effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB).


Sixty CHB patients were randomly assigned to either usual care or hydrogen therapy, in which patients received usual care alone or plus oral HRW (1200-1800 mL/day twice daily) for 6 weeks. Serum oxidative stress, liver function and HBV DNA levels were detected before and after treatment. 30 healthy volunteers served as controls.


Compared with the control group, the oxidative stress and liver function were significantly impaired in patients with chronic hepatitis B. After treatment, oxidative stress remained unchanged in the conventional treatment group, but significantly improved in the hydrogen treatment group. After appropriate treatment, liver function was significantly improved and HBV DNA was significantly reduced. Although there was a significant difference in oxidative stress between the two groups after treatment, liver function and HBV DNA levels were comparable after treatment, both showing a trend of improvement.


HRW significantly reduced oxidative stress in CHB patients, but further studies with long-term treatment are needed to confirm the effect of HRW on liver function and HBV DNA levels. Clinical Interscience 2013; Volume #: 1-4


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