Hydrogen therapy is more effective than oxygen therapy in COPDScientific Research
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
To investigate whether the use of a hydrogen/oxygen mixture is superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
This prospective, randomized, double-blind, controlled, 10-center clinical study enrolled patients with AECOPD and a BCSS (dyspnea, cough and sputum scale) score of at least 6. Eligible patients were randomly assigned (1:1 ratio) to receive hydrogen/oxygen hybrid therapy or oxygen therapy. The primary endpoint was change from baseline in BCSS score at day 7. Adverse events (AEs) were recorded to assess safety.
The change in BCSS score was greater in the hydrogen/oxygen group than in the oxygen group (-5.3 vs. -2.4 points; difference: -2.75 [95% CI -3.27 to – 2:22], which met superiority criteria). Similar results were observed at other time points from day 2 to day 6. Cough assessment test scores were significantly lower in the hydrogen/oxygen group compared to the control group (-11.00 vs -6.00, p<0.001). Changes in lung function, arterial blood gases, and noninvasive oxygen saturation did not differ significantly between groups, as well as for other endpoints. AEs were reported in 34 (63.0%) patients in the hydrogen/oxygen group and in 42 (77.8%) patients in the oxygen group. No deaths or equipment failures were reported during the study period.
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