H2-rich saline prevents doxorubicin-induced heart failureScientific Research

original title: Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats

Authors:

Shujing Wu, Liqun Zhu, Jing Yang, Zhixin Fan, Yanli Dong, Rui Luan, Jingjing Cai, Lu Fu

DOI: 10.1691/ph.2014.3859

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Abstract:

Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.