Upregulation of H2-Related Genes with Hydrogen WaterScientific Research

original title: Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water

Authors:

Yuji Nakai, Bunpei Sato, Shota Ushiama, Shinji Okada, Keiko Abe, Soichi Arai

DOI: 10.1271/bbb.100819

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Abstract:

The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.