H2 boosts bone formation in zebrafish embryosScientific Research

original title: Molecular hydrogen enhances osteogenesis in Danio rerio embryos


Marta Carnovali, Massimo Mariotti, Giuseppe Banfi

DOI: 10.1111/jfb.14670



Molecular hydrogen (H2 ) has been reported to have important biological effects on bone tissue in several in vitro and in vivo models. Danio rerio (zebrafish) embryo is a good model to study osteogenesis because its transparency, size and rapid development. In zebrafish embryo, hydrogen rich water (HRW) do not affect vitality or growth rate up to 15%. In addition, 7% HRW treatment enhances zebrafish embryo osteogenesis increasing vertebral mineralization rate. In conclusion, we demonstrated the beneficial effects of hydrogen on anabolic bone functions in vivo. This article is protected by copyright. All rights reserved.