H2-Enriched Water and Longevity: A Murine StudyScientific Research

original title: Alkaline Water and Longevity: A Murine Study


Massimiliano Magro, Livio Corain, Silvia Ferro, Davide Baratella, Emanula Bonaiuto, Milo Terzo, Vittorino Corraducci, Luigi Salmaso, Fabio Vianello

DOI: 10.1155/2016/3084126



The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model. Starting from the second year of life, nonparametric survival plots suggest that mice watered with alkaline water showed a better survival than control mice. Interestingly, statistical analysis revealed that alkaline water provides higher longevity in terms of “deceleration aging factor” as it increases the survival functions when compared with control group; namely, animals belonging to the population treated with alkaline water resulted in a longer lifespan. Histological examination of mice kidneys, intestine, heart, liver, and brain revealed that no significant differences emerged among the three groups indicating that no specific pathology resulted correlated with the consumption of alkaline water. These results provide an informative and quantitative summary of survival data as a function of watering with alkaline water of long-lived mouse models.