H2 Generation via Electron Attachment to Resveratrol in MitochondriaScientific Research

original title: Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H 2 Antioxidant Species Inside Mitochondria


Stanislav A Pshenichnyuk, Alexei S Komolov

DOI: 10.1021/acs.jpclett.5b00368



The electron-attaching properties of polyphenolic compound resveratrol were studied in vacuo by means of dissociative electron attachment (DEA) spectroscopy and in silico using density functional theory calculations. The most intense fragments generated by DEA to isolated resveratrol at thermal electron energy are semiquinone anions and neutral hydrogen molecules. On the basis of the present experimental and theoretical data, a new molecular mechanism for the antioxidant activity of resveratrol is presented. It is suggested that the activity of resveratrol in living cells is driven by dissociative attachment of electrons “leaked” from the respiratory chain to this polyphenolic molecule, followed by the formation of the H2 antioxidant species inside mitochondria and participation in mitochondrial energy biogenesis.